abstract：:Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death and is currently the main event leading to death in patients with cirrhosis. Evolving information suggests that the metabolic syndrome with non-alcoholic liver disease may be an important cause of HCC in addition to viral hepatitis and...

journal_title：Gut

authors： Bruix J,Gores GJ,Mazzaferro V

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVES:Emerging evidence from mouse models suggests that mutant Kras can drive the development of pancreatic ductal adenocarcinoma (PDA) precursors from acinar cells by enforcing ductal de-differentiation at the expense of acinar identity. Recently, human genome-wide association studies have identified NR5A2, a key...

journal_title：Gut

authors： von Figura G,Morris JP 4th,Wright CV,Hebrok M

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:To investigate the potential tumour suppressor functions of glutathione peroxidase 7 (GPX7) and examine the interplay between epigenetic and genetic events in regulating its expression in oesophageal adenocarcinomas (OAC). DESIGN:In vitro and in vivo cell models were developed to investigate the biological a...

journal_title：Gut

authors： Peng D,Hu T,Soutto M,Belkhiri A,Zaika A,El-Rifai W

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:Whether peginterferon α and ribavirin combination therapy reduces risk of hepatocellular carcinoma (HCC) or improves survival in patients dual-infected with hepatitis C virus (HCV) and hepatitis B virus (HBV) is unknown. Since it is ethically impossible to conduct a randomised trial to learn the long-term eff...

journal_title：Gut

authors： Liu CJ,Chu YT,Shau WY,Kuo RN,Chen PJ,Lai MS

更新日期：2014-03-01 00:00:00

abstract：UNLABELLED:Data on the natural history of elderly-onset inflammatory bowel disease (IBD) are scarce. METHODS:In a French population-based cohort we identified 841 IBD patients >60 years of age at diagnosis from 1988 to 2006, including 367 Crohn's disease (CD) and 472 ulcerative colitis (UC). RESULTS:Median age at dia...

journal_title：Gut

authors： Charpentier C,Salleron J,Savoye G,Fumery M,Merle V,Laberenne JE,Vasseur F,Dupas JL,Cortot A,Dauchet L,Peyrin-Biroulet L,Lerebours E,Colombel JF,Gower-Rousseau C

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVES:No trial has compared non-bismuth quadruple 'sequential' and 'concomitant' regimens in settings with increasing clarithromycin rates. The study aims to compare the effectiveness and safety of these therapies for Helicobacter pylori treatment. DESIGN:Prospective randomised clinical trial in 11 Spanish hospit...

journal_title：Gut

authors： McNicholl AG,Marin AC,Molina-Infante J,Castro M,Barrio J,Ducons J,Calvet X,de la Coba C,Montoro M,Bory F,Perez-Aisa A,Forné M,Gisbert JP,Participant Centres.

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:The aetiology of Crohn's disease (CD) has been related to nucleotide-binding oligomerisation domain containing 2 (NOD2) and ATG16L1 gene variants. The observation of bacterial DNA translocation in patients with CD led us to hypothesise that this process may be facilitated in patients with NOD2/ATG16L1-variant...

journal_title：Gut

authors： Gutiérrez A,Scharl M,Sempere L,Holler E,Zapater P,Almenta I,González-Navajas JM,Such J,Wiest R,Rogler G,Francés R

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Most colon cancers start with dysregulated Wnt/β-catenin signalling and remain a major therapeutic challenge. Examining whether HAMLET (human α-lactalbumin made lethal to tumour cells) may be used for colon cancer treatment is logical, based on the properties of the complex and its biological context. OBJEC...

journal_title：Gut

authors： Puthia M,Storm P,Nadeem A,Hsiung S,Svanborg C

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:Cryptogenic multifocal ulcerating stenosing enteritis (CMUSE) is an extremely rare, but devastating, disease of unknown aetiology. We investigated the genetic basis of this autosomal recessive condition in a pair of affected siblings who have 40-year histories of catastrophic gastrointestinal and extraintesti...

journal_title：Gut

authors： Brooke MA,Longhurst HJ,Plagnol V,Kirkby NS,Mitchell JA,Rüschendorf F,Warner TD,Kelsell DP,MacDonald TT

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:Loss of surface maturation and cytonuclear atypia have been regarded as the pathological 'gold standard' for the diagnosis of oesophageal squamous cell intraepithelial neoplasia. However, there has been no satisfactory endomicroscopic method similar to this pathological approach to detect surface maturation a...

journal_title：Gut

authors： Li M,Zuo XL,Yu T,Gu XM,Zhou CJ,Li Z,Liu H,Ji R,Dong YY,Li CQ,Li YQ

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:In the revised Atlanta classification of acute pancreatitis, the term necrotising pancreatitis also refers to patients with only extrapancreatic fat necrosis without pancreatic parenchymal necrosis (EXPN), as determined on contrast-enhanced CT (CECT). Patients with EXPN are thought to have a better clinical o...

journal_title：Gut

authors： Bakker OJ,van Santvoort H,Besselink MG,Boermeester MA,van Eijck C,Dejong K,van Goor H,Hofker S,Ahmed Ali U,Gooszen HG,Bollen TL,Dutch Pancreatitis Study Group.

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:Persistent colonisation by Helicobacter pylori, and especially by cagA-positive strains, has been related to several health outcomes with effects in opposite directions. Thus, it is important to evaluate its influence on total and category-specific mortality. DESIGN:We conducted prospective cohort analyses i...

journal_title：Gut

authors： Chen Y,Segers S,Blaser MJ

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Fibrosis associated with chronic pancreatitis is an irreversible lesion that can disrupt pancreatic exocrine and endocrine function. Currently, there are no approved treatments for this disease. We previously showed that siRNA against collagen-specific chaperone protein gp46, encapsulated in vi...

journal_title：Gut

authors： Ishiwatari H,Sato Y,Murase K,Yoneda A,Fujita R,Nishita H,Birukawa NK,Hayashi T,Sato T,Miyanishi K,Takimoto R,Kobune M,Ota S,Kimura Y,Hirata K,Kato J,Niitsu Y

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:Lesogaberan (AZD3355) is a novel γ-aminobutyric acid B-type receptor agonist designed to treat gastro-oesophageal reflux disease (GERD) by inhibiting transient lower oesophageal sphincter relaxations. A randomised, double-blind, placebo-controlled, multi-centre phase IIb study was performed to assess the effi...

journal_title：Gut

authors： Shaheen NJ,Denison H,Björck K,Karlsson M,Silberg DG

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVES:Screening colonoscopy to monitor for early colitis-associated colon cancer (CAC) is difficult due to the aberrant mucosal patterns associated with long-standing colitis. The aim of this study was to develop a rapid fluorescent detection method for use during colonoscopy for improving the detection of CAC uti...

journal_title：Gut

authors： Mitsunaga M,Kosaka N,Choyke PL,Young MR,Dextras CR,Saud SM,Colburn NH,Sakabe M,Nagano T,Asanuma D,Urano Y,Kobayashi H

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVE:To highlight the contribution of the gut microbiota to the modulation of host metabolism by dietary inulin-type fructans (ITF prebiotics) in obese women. METHODS:A double blind, placebo controlled, intervention study was performed with 30 obese women treated with ITF prebiotics (inulin/oligofructose 50/50 mi...

journal_title：Gut

authors： Dewulf EM,Cani PD,Claus SP,Fuentes S,Puylaert PG,Neyrinck AM,Bindels LB,de Vos WM,Gibson GR,Thissen JP,Delzenne NM

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVES:Novel imaging methods based on specific molecular targets to detect both established neoplasms and their precursor lesions are highly desirable in cancer medicine. Previously, we identified claudin-4, an integral constituent of tight junctions, as highly expressed in various gastrointestinal tumours includin...

journal_title：Gut

authors： Neesse A,Hahnenkamp A,Griesmann H,Buchholz M,Hahn SA,Maghnouj A,Fendrich V,Ring J,Sipos B,Tuveson DA,Bremer C,Gress TM,Michl P

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVES:The postinfectious irritable bowel syndrome (PI-IBS) suggests that impaired resolution of inflammation could cause IBS symptoms. The authors hypothesised that polymorphisms in genes whose expression were altered by gastroenteritis might be linked to IBS with diarrhoea (IBS-D) which closely resembles PI-IBS. ...

journal_title：Gut

authors： Swan C,Duroudier NP,Campbell E,Zaitoun A,Hastings M,Dukes GE,Cox J,Kelly FM,Wilde J,Lennon MG,Neal KR,Whorwell PJ,Hall IP,Spiller RC

更新日期：2013-07-01 00:00:00

abstract：:Probiotics are derived from traditional fermented foods, from beneficial commensals or from the environment. They act through diverse mechanisms affecting the composition or function of the commensal microbiota and by altering host epithelial and immunological responses. Certain probiotic interventions have shown prom...

journal_title：Gut

authors： Sanders ME,Guarner F,Guerrant R,Holt PR,Quigley EM,Sartor RB,Sherman PM,Mayer EA

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:To develop gene expression profiles that characterise KRAS-, BRAF- or PIK3CA-activated- tumours, and to explore whether these profiles might be helpful in predicting the response to the epidermal growth factor receptor (EGFR) pathway inhibitors better than mutation status alone. DESIGN:Fresh frozen tumour sa...

journal_title：Gut

authors： Tian S,Simon I,Moreno V,Roepman P,Tabernero J,Snel M,van't Veer L,Salazar R,Bernards R,Capella G

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:Cathepsin K is a lysosomal cysteine protease that has pleiotropic roles in bone resorption, arthritis, atherosclerosis, blood pressure regulation, obesity and cancer. Recently, it was demonstrated that cathepsin K-deficient (Ctsk(-/-) ) mice are less susceptible to experimental autoimmune arthritis and enceph...

journal_title：Gut

authors： Sina C,Lipinski S,Gavrilova O,Aden K,Rehman A,Till A,Rittger A,Podschun R,Meyer-Hoffert U,Haesler R,Midtling E,Pütsep K,McGuckin MA,Schreiber S,Saftig P,Rosenstiel P

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Most direct understanding of enteric nerve (patho)physiology has been obtained by electrode and imaging techniques in animal models and human surgical samples. Until now, neuronal activity recordings from a more accessible human tissue source have remained a true challenge. OBJECTIVES:To record nerve activi...

journal_title：Gut

authors： Cirillo C,Tack J,Vanden Berghe P

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Lynch syndrome is caused by germline mismatch repair (MMR) gene mutations. The PREMM(1,2,6) model predicts the likelihood of a MMR gene mutation based on personal and family cancer history. OBJECTIVE:To compare strategies using PREMM(1,2,6) and tumour testing (microsatellite instability (MSI) and/or immunoh...

journal_title：Gut

authors： Kastrinos F,Steyerberg EW,Balmaña J,Mercado R,Gallinger S,Haile R,Casey G,Hopper JL,LeMarchand L,Lindor NM,Newcomb PA,Thibodeau SN,Syngal S,Colon Cancer Family Registry.

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND AND AIM:The lymphatic network plays a major role in maintaining tissue fluid homoeostasis. Therefore several pathological conditions associated with oedema formation result in deficient lymphatic function. However, the role of the lymphatic system in the pathogenesis of ascites and oedema formation in cirrho...

journal_title：Gut

authors： Ribera J,Pauta M,Melgar-Lesmes P,Tugues S,Fernández-Varo G,Held KF,Soria G,Tudela R,Planas AM,Fernández-Hernando C,Arroyo V,Jiménez W,Morales-Ruiz M

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Progression of a colorectal adenoma to invasive cancer occurs in a minority of adenomas and is the most crucial step in colorectal cancer pathogenesis. In the majority of cases, this is associated with gain of a substantial part of chromosome 20q, indicating that multiple genes on the 20q ampli...

journal_title：Gut

authors： Sillars-Hardebol AH,Carvalho B,Tijssen M,Beliën JA,de Wit M,Delis-van Diemen PM,Pontén F,van de Wiel MA,Fijneman RJ,Meijer GA

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are important in hepatic pathophysiology and the development of liver cancer. OBJECTIVE:To explore miRNAs that are regulated with the progression of liver fibrosis caused by chronic liver disease. DESIGN:The regulated miRNAs in human livers infected with hepatitis C virus were identified...

journal_title：Gut

authors： Ogawa T,Enomoto M,Fujii H,Sekiya Y,Yoshizato K,Ikeda K,Kawada N

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:The risk of colorectal cancer after a previous negative colonoscopy is very low. Nevertheless, interval cancers occur. We aimed to assess the characteristics and predictors of interval cancers after negative colonoscopy. METHODS:A population-based case-control study was conducted in Southern Germany in 2003-...

journal_title：Gut

authors： Brenner H,Chang-Claude J,Seiler CM,Hoffmeister M

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Knowledge on the aetiology of exocrine pancreatic cancer (EPC) is scant. The best established risk factor for EPC is tobacco smoking. Among other carcinogens, tobacco contains cadmium, a metal previously associated with an increased risk of EPC. This study evaluated the association between concentra...

journal_title：Gut

authors： Amaral AF,Porta M,Silverman DT,Milne RL,Kogevinas M,Rothman N,Cantor KP,Jackson BP,Pumarega JA,López T,Carrato A,Guarner L,Real FX,Malats N

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:Conventional colonoscopy (CC) is considered the reference standard for detection of colorectal neoplasia, but it can still miss a substantial number of adenomas. The use of a transparent plastic cap may improve colonic visualisation. Cap-assisted colonoscopy (CAC) was compared with CC for adenoma detection. S...

journal_title：Gut

authors： de Wijkerslooth TR,Stoop EM,Bossuyt PM,Mathus-Vliegen EM,Dees J,Tytgat KM,van Leerdam ME,Fockens P,Kuipers EJ,Dekker E

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNA) have potential as prognostic biomarkers and therapeutic targets in cancer. A study was undertaken to investigate the association between miRNA expression patterns and the prognosis and therapeutic outcome of colorectal cancer (CRC). METHODS:miRNA expression profiling in tumour, adenoma and...

journal_title：Gut

authors： Ma Y,Zhang P,Wang F,Zhang H,Yang J,Peng J,Liu W,Qin H

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Pigment epithelium-derived factor (PEDF), a non-inhibitory SERPIN with potent antiangiogenic activity, has been recently implicated in metabolism and adipogenesis, both of which are known to influence pancreatic cancer progression. Increased pancreatic fat in human pancreatic tumour correlates with ...

journal_title：Gut

authors： Grippo PJ,Fitchev PS,Bentrem DJ,Melstrom LG,Dangi-Garimella S,Krantz SB,Heiferman MJ,Chung C,Adrian K,Cornwell ML,Flesche JB,Rao SM,Talamonti MS,Munshi HG,Crawford SE

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:Exposure of the oesophageal mucosa to gastric acid and bile acids leads to the accumulation of reactive oxygen species (ROS), a known risk factor for Barrett's oesophagus and progression to oesophageal adenocarcinoma (OAC). This study investigated the functions of glutathione peroxidase 7 (GPX7), frequently s...

journal_title：Gut

authors： Peng D,Belkhiri A,Hu T,Chaturvedi R,Asim M,Wilson KT,Zaika A,El-Rifai W

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVES:Loss of intestinal barrier function plays an important role in the pathogenesis of inflammatory bowel disease (IBD). Shedding of intestinal epithelial cells is a potential cause of barrier loss during inflammation. The objectives of the study were (1) to determine whether cell shedding and barrier loss in hu...

journal_title：Gut

authors： Kiesslich R,Duckworth CA,Moussata D,Gloeckner A,Lim LG,Goetz M,Pritchard DM,Galle PR,Neurath MF,Watson AJ

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:Using genome-wide promoter methylation assay, B cell CLL/lymphoma 6 member B (BCL6B) was found to be preferentially methylated in cancer. A study was undertaken to examine the epigenetic regulation, biological function and clinical significance of BCL6B in gastric cancer (GC). METHODS:BCL6B promoter methylat...

journal_title：Gut

authors： Xu L,Li X,Chu ES,Zhao G,Go MY,Tao Q,Jin H,Zeng Z,Sung JJ,Yu J

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND AND AIMS:The authors' goal was to measure pH at the gastric surface (pH₀) to understand how acid secretion affects the repair of microscopic injury to the gastric epithelium. METHODS:Microscopic gastric damage was induced by laser light, during confocal/two-photon imaging of pH-sensitive dyes (Cl-NERF, BCEC...

journal_title：Gut

authors： Demitrack ES,Aihara E,Kenny S,Varro A,Montrose MH

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:Reports on the effects of bone marrow-derived cells on hepatic fibrosis are contradictory. Impaired fibrosis but increased inflammation has recently been demonstrated 10 weeks after bone marrow transplantation (BM-Tx) in Abcb4-/- mice. It is hypothesised that BM-Tx might have long-term therapeutic potential b...

journal_title：Gut

authors： Roderfeld M,Rath T,Pasupuleti S,Zimmermann M,Neumann C,Churin Y,Dierkes C,Voswinckel R,Barth PJ,Zahner D,Graf J,Roeb E

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, may play a critical role in many chronic pain conditions. The possible involvement of BDNF in the altered gut sensation in patients with irritable bowel syndrome (IBS) was investigated in the present study. METHODS:Rectosigmoid bi...

journal_title：Gut

authors： Yu YB,Zuo XL,Zhao QJ,Chen FX,Yang J,Dong YY,Wang P,Li YQ

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:It is postulated that high serum levels of insulin and insulin growth factor 1 (IGF-1) mediate obesity-associated carcinogenesis. The relationship of insulin, IGF-1 and IGF binding proteins (IGFBP) with Barrett's oesophagus (BO) has not been well examined. METHODS:Serum levels of insulin and IGFBPs in patie...

journal_title：Gut

authors： Greer KB,Thompson CL,Brenner L,Bednarchik B,Dawson D,Willis J,Grady WM,Falk GW,Cooper GS,Li L,Chak A

更新日期：2012-05-01 00:00:00

abstract：:Hepatitis B and hepatitis C infections are important causes of end-stage liver disease and primary liver cancer. Successful antiviral treatment prior to the development of cirrhosis will prevent most of the morbidity and mortality associated with those infections. This can be achieved for a high proportion of patients...

journal_title：Gut

authors： Mutimer DJ,Lok A

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND AND AIMS:The authors have previously isolated a putative oncogene, eukaryotic initiation factor 5A2 (EIF5A2) from 3q26. In this study, EIF5A2 was characterised for its role in colorectal carcinoma (CRC) aggressiveness and underlying molecular mechanisms. METHODS:The expression dynamics of EIF5A2 were examin...

journal_title：Gut

authors： Zhu W,Cai MY,Tong ZT,Dong SS,Mai SJ,Liao YJ,Bian XW,Lin MC,Kung HF,Zeng YX,Guan XY,Xie D

更新日期：2012-04-01 00:00:00